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Treatment of Vulvar Melanoma

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Vulvar melanoma is a rare but serious cancer that develops in the pigment-producing cells of the vulva. Treatment depends on the size of the tumor and whether it has spread. The main treatment is surgery, the same as that for vulvar squamous carcinoma and adenocarcinoma. 

A partial vulvectomy (surgery to remove the tumor and a rim of healthy tissue around it), along with lymph node removal is the usual treatment for melanoma on the vulva. In some cases, radiation therapy, chemotherapy, immunotherapy, and targeted drug therapy may also be used. These decisions are made on a case-by-case basis.

Treatment options depend on:

  • How deep the melanoma is
  • Where it is on the skin of the vulva
  • Whether it's ulcerated (an open sore)
  • Spread to lymph nodes

The cancer stage and the woman's age and personal preferences are also key.

If the melanoma has spread outside the vulva, other treatments may be needed. More on treatment of vulvar melanoma can be found in Melanoma Skin Cancer

Because vulvar melanoma has a high chance of coming back, regular doctor visits and scans are important. Patients may need check-ups every few months to monitor for any signs of cancer returning. Routine skin exams can also help find new melanomas early.

side by side logos for American Cancer Society and American Society of Clinical Oncology

Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

 

National Cancer Institute. Vulvar Cancer Treatment (PDQ®)–Patient Version. September 18, 2024. Accessed at www.cancer.gov/types/vulvar/patient/vulvar-treatment-pdq#section/_90 on February 17, 2025.

 

Last Revised: January 16, 2018

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